Our society gets older, people live longer. The price we pay: infectious diseases can easier overcome the immune system. Like all organs, the immune system does not function flawlessly in old age and for that reason also prophylactic tools like vaccinations do not work properly in the elderly. Under the coordination of the Helmholtz Centre for Infection Research (Carlos A Guzmán) university and non-university research institutes and two companies joined forces in the GERONTOSHIELD project to investigate why our immune defense is getting weaker when we become old. The strategic objective of the project is to draw on a Systems Biology-driven approach to understand the molecular processes affected during immunosenescence to derive strategies to overcome them in order to establish effective immune interventions tailored for the elderly.
Recently accepted for publication
Riese P., Schulze K., Ebensen T., Prochnow B., Guzmán CA. (2013). Vaccine adjuvants: key tools for innovative vaccine design. Curr Top Med Chem. 13(20):2562-80.
Wistuba-Hamprecht K., Frasca D., Blomberg B., Pawelec G., Derhovanessian E. (2013). Age-associated alterations in γδ T-cells are present predominantly in individuals infected with Cytomegalovirus. Immun Ageing. 10(1):26.
Derhovanessian E., Theeten H., Hähnel K., Van Damme P., Cools N., Pawelec G. (2013). Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination. Vaccine. 31(4):685-90.
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