Gerontoshield

Gerontoshield

Publications emerging from the project

  • Binder S., Telschow A., Meyer-Hermann M. (2012). Population dynamics of Borrelia burgdorferi in Lyme disease. Front. Microb. Immunol. 3:104.
  • Buffa S., Pellicanò M., Bulati M., Martorana A., Goldeck D., Caruso C., Pawelec G., Colonna-Romano G. (2012). A novel B cell population revealed by a CD38/CD24 gating strategy: CD38(-) CD24 (-) B cells in centenarian offspring and elderly people. Age (Dordr). doi: 10.1007/s11357-012-9488-5.
  • Derhovanessian E., Maier A.B., Hähnel K., Zelba H., de Craen A.J., Roelofs H., Slagboom E.P., Westendorp R.G., Pawelec G. (2013). Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people. Age (Dordr). 35(4):1387-99.
  • Derhovanessian E., Pawelec G. (2012). Vaccination in the elderly. Microb Biotechnol. 5(2):226-32.
  • Derhovanessian E., Theeten H., Hähnel K., Van Damme P., Cools N., Pawelec G. (2013). Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination. Vaccine. 31(4):685-90.
  • Dustin ML., Meyer-Hermann M. (2012). Antigen feast or famine. Science 335:408-9.
  • Fava* E., Dehghany* J., Ouwendijk J., Müller A., Niederlein A., Verkade P., Meyer-Hermann* M., Solimena* M. (2012). Novel standards in the measurement of insulin granules combining electron microscopy, high-content image analysis and in silico modelling. Diabetologia 55:1013-23. [*shared first and shared corresponding author].
  • Fülöp T., Lacombe G., Cunnane S., Le Page A., Dupuis G., Frost EH., Bourgade-Navarro K., Goldeck D., Larbi A., Pawelec G. (2013). Elusive Alzheimer's disease: can immune signatures help our understanding of this challenging disease? Part 1: clinical and historical background.  Discov Med. 15(80):23-32.
  • Fülöp T., Lacombe G., Cunnane S., Le Page A., Dupuis G., Frost EH., Bourgade-Navarro K., Goldeck D., Larbi A., Pawelec G. (2013). Elusive Alzheimer's disease: can immune signatures help our understanding of this challenging disease? Part 2: new immune paradigm. Discov Med. 15(80):33-42.
  • Fülöp T., Larbi A., Exterman M., Solana R., Dupuis G., Kotb R., Derhovanassian E., Pawelec G. (2013). Aging, Immunosenescence, and Cancer, in Inflammation, Advancing Age and Nutrition: Research and Clinical Interventions (Eds Irfan Rahman and Debasis Bagchi), 1edn. Academic Press, p55-69.
  • Hernandez-Vargas E., Colaneri P., Middleton R. (2013). Switching strategies to mitigate HIV mutation, IEEE Transactions in Control Systems and Technology, accepted for publication.
  • Hernandez-Vargas E., Middleton R. (2013). Modeling the three stages in HIV infection, Journal of Theoretical Biology, Vol. 320, 33-40.
  • Ioannou K., Derhovanessian E., Tsakiri E., Samara P., Kalbacher H., Voelter W., Trougakos I.P., Pawelec G., Tsitsilonis O.E. (2013). Prothymosin α and a prothymosin α-derived peptide enhance T(H)1-type immune responses against defined HER-2/neu epitopes. BMC Immunol. 14:43.
  • Libanova R., Becker PD., and Guzmán CA. (2012). Cyclic di-nucleotides: new era for small molecules as adjuvants. Microb Biotechnol. 5(2):168-76.
  • Meyer-Hermann M., Mohr E., Pelletier N., Zhang Y., Victora GD., Toellner K-M. (2012). A theory of germinal center B cell selection, division and exit. Cell Reports 2:162-74.
  • Pawelec G. (2012). Hallmarks of human "immunosenescence": adaptation or dysregulation? Immun Ageing. 9(1):15.
  • Pawelec G., McElhaney JE., Aiello AE., Derhovanessian E. (2012). The impact of CMV infection on survival in older humans. Curr Opin Immunol. 24(4):507-11.
  • Pellicanò M., Buffa S., Goldeck D., Bulati M., Martorana A., Caruso C., Colonna-Romano G., Pawelec G. (2013). Evidence for Less Marked Potential Signs of T-Cell Immunosenescence in Centenarian Offspring Than in the General Age-Matched Population. J Gerontol A Biol Sci Med Sci. Aug 24.
  • Riese P., Schulze K., Ebensen T., Prochnow B., Guzmán CA. (2013). Vaccine adjuvants: key tools for innovative vaccine design. Curr Top Med Chem. 13(20):2562-80.
  • Rueckert C., Guzmán CA. (2012). Vaccines: from empirical development to rational design. PLoS Pathog. 8(11): e1003001. doi: 10.1371/journal. ppat.1003001.
  • Stavrum AK., Heiland I., Schuster S., Puntervoll P., Ziegler M. (2013). Model of tryptophan metabolism, readily scalable using tissue-specific gene expression data. Journal of Biological Chemistry, 288:34555-66.
  • Sukhorukov V., Dikov D., Reichert AS., Meyer-Hermann M. (2012). Emergence of the mitochondrial reticulum from fission and fusion dynamics. PLoS Comput. Biol. 8(10):e1002745.
  • Tokarski C., Hummert S., Mech F., Figge MT., Germerodt S., Schroeter A. and Schuster S. (2012) Agent-based modeling approach of immune defense against spores of opportunistic human pathogenic fungi. Front. Microbio. 3:129. doi: 10.3389/fmicb.2012.00129.
  • Wistuba-Hamprecht K., Frasca D., Blomberg B., Pawelec G., Derhovanessian E. (2013). Age-associated alterations in γδ T-cells are present predominantly in individuals infected with Cytomegalovirus. Immun Ageing. 10(1):26.
  • Zhang* Y., Meyer-Hermann* M., et al. (2013). Germinal centre B cells govern their own fate via antibody feedback. J. Exp. Med. 210: 457-464. [*shared first author].

Relevant publications

  • Beuster G., Zarse K., Kaleta C., Thierbach R:, Kiehntopf M., Steinberg P., Schuster S., Ristow M. (2011). Inhibition of alanine aminotransferase (ALAT) in silico and in vivo promotes mitochondrial metabolism to impair malignant growth. J. Biol. Chem. 286:22323-30.
  • Beyer, T., Meyer-Hermann, M. (2008). Cell transmembrane receptors determine tissue pattern stability. Phys. Rev. Lett. 101:148102.
  • de Figueiredo LF., Gossmann TI., Ziegler M., Schuster S. (2011). Pathway Analysis of NAD+ metabolism. Biochem. J. 439:341-348.
  • Derhovanessian E., Maier AB., Hähnel K., Beck R., de Craen AJ., Slagboom EP., Westendorp RG., Pawelec G. (2011). Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late differentiated CD4+ and CD8+ T-cells in humans. J Gen Virol. 92:2746-56.
  • Derhovanessian E., Maier AB., Beck R., Jahn G., Hähnel K., Slagboom PE., De Craen AJM., Westendorp RGJ., Pawelec G. (2010). Hallmark features of immunosenescence are absent in familial longevity. J Immunol 185:4618-24.
  • Derhovanessian E., Larbi A., Pawelec G. (2009). Biomarkers of human immunosenescence: impact of Cytomegalovirus infection. Curr Op Immunol 21:440-5.
  • Ebensen T., Libanova R., Schulze K., Yevsa T., Morr M., Guzmán CA. (2011). Bis-(3',5')-cyclic dimeric adenosine monophosphate: Strong Th1/Th2/Th17 promoting mucosal adjuvant. Vaccine 29(32):5210-20.
  • Ebensen T., Guzmán C.A. (2009). Immune modulators with defined molecular targets: cornerstone to optimize rational vaccine design. Advances in Experimental Medicine and Biology 655:171-88.
  • Ebensen T., Guzmán C.A. (2008). Immune modulators with defined molecular targets: cornerstone to optimize rational vaccine design. Human Vaccines 4(1):13-22.
  • Ebensen T., Link C., Riese P., Schulze K., Morr M., Guzmán CA. (2007). A pegylated derivative of alpha-galactosylceramide exhibits improved biological properties. J Immunol 179(4):2065-73.
  • Ebensen T., Schulze K., Riese P., Morr M., Guzmán CA. (2007). The bacterial second messenger cdiGMP exhibits promising activity as a mucosal adjuvant. Clinical and Vaccine Immunology 14(8):952-8.
  • Ebensen T, Schulze K, Riese P., Link C., Morr M., Guzmán CA. (2007). The bacterial second messenger cyclic diGMP exhibits potent adjuvant properties. Vaccine 25(8):1464-1469.
  • Figge MT., Meyer-Hermann M. (2009). Modeling receptor-ligand binding kinetics in immunological synapse formation. Eur. Phys. J. D 51:153-60.
  • Figge MT., Garin A., Gunzer M., Kosco-Vilbois M., Toellner K-M., Meyer-Hermann M. (2008). Deriving a germinal center lymphocyte migration model from two-photon data, J. Exp. Med. 205, 3019-3029.
  • Figge MT., Meyer-Hermann M. (2006). Geometrically re-patterned immunological synapses uncover formation mechanisms. PLoS Comput. Biol. 2:e171.
  • Fulop T., Larbi A., Kotb R., de Angelis F., Pawelec G. (2011). Aging, immunity, and cancer. Discov Med. 11:537-50.
  • Fulop T., Larbi A., Witkowski JM., McElhaney J., Loeb M., Mitnitski A., Pawelec G. (2010). Aging, frailty and age-related diseases. Biogerontology. 11:547-63.
  • Fulop T., Pawelec G., Castle .S, Loeb M. (2009). Immunosenescence and Vaccination in Nursing Home Residents. Clin Infect Dis. 48:443-8.
  • Garin* A., Meyer-Hermann* M., Contie M., Figge MT., Buatois V., Gunzer M., Toellner K-M., Elson G., Kosco-Vilbois MH. (2010). Toll-Like Receptor 4 signaling by Follicular Dendritic Cells is pivotal for germinal center onset and affinity maturation. Immunity 33:84-95. [*shared first author]
  • Ghedira K., Hornischer K., Konovalova T., Jenhani A.Z., Benkahla A., Kel A. (2011). Identification of key mechanisms controlling gene expression in Leishmania infected macrophages using genome-wide promoter analysis. Infect. Genet. Evol. 11:769-77.
  • Guzmán CA. (2010). Optimizing rational vaccine design. Microbial Biotechnology 2(2):136-8.
  • Hummert S., Hummert C., Schroter A., Hube B., Schuster S. (2010). Game theoretical modelling of survival strategies of Candida albicans inside macrophages. J. Theor. Biol. 264:312-8.
  • Kosco-Vilbois M., Meyer-Hermann M. (2009). The 16th international conference on lymphatic tissues and germinal centres in immune responses, Eur. J. Immunol. 39:2311-2.
  • Larbi A., Pawelec G., Wong SC., Goldeck D., Tai JJ., Fulop T. (2011). Impact of age on T cell signalling. Ageing Res Rev 10:370-8.
  • Larbi A., Cabreiro F., Zelba H., Marthandan S., Combet E., Friguet B., Petropoulos I., Barnett Y., Pawelec G. (2010). Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation. Free Radic Biol Med. 48:26.
  • Libanova R., Ebensen T., Schulze K., Bruhn D., Norder M., Yevsa T., Morr M., Guzmán C.A. (2010). The member of the cyclic di-nucleotide family bis-(3', 5')-cyclic dimeric inosine monophosphate exerts potent activity as mucosal adjuvant. Vaccine 28(10):2249-58.
  • Luber CA, Cox J, Lauterbach H, Fancke B, Selbach M, Tschopp J, Akira S, Wiegand M, Hochrein H, O'Keeffe M, Mann M. (2010). Quantitative proteomics reveals subset-specific viral recognition in dendritic cells. Immunity. 32(2):279-89.
  • Madhun AS., Haaheim LR., Nostbakken JK., Ebensen T., Chichester J., Yusibov V.; Guzmán,Carlos A.; Cox,R.J.; (2011). Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4(+) cells and strong mucosal and systemic antibody responses in mice. Vaccine 29(31):4973-82.
  • Meyer-Hermann, M., Figge, M.T., Straub, R. (2009): Mathematical modeling of the circadian rhythm of key neuroendocrine immune players in rheumatoid arthritis: A systems biology approach, Arthritis & Rheumatism: 60, 2585-2594.
  • Meyer-Hermann M., Figge MT., Toellner KM. (2009). Germinal centres seen through the mathematical eye: B cell models on the catwalk, review invited by Trends Immunol. 30:57-164.
  • Meyer-Hermann, M. (2007). B cell selection mechanisms revisited: A concerted action. Adv. Compl. Sys. 10:557-80.
  • Meyer-Hermann M., Maini PK., Iber D. (2006). An analysis of B cell selection mechanisms in germinal centers. Math. Med. Biol. 23:255-77.
  • Mortensen LH, Maier AB, Slagbom PE, Pawelec G, Derhovanessian E, Petersen I, Jahn G, Westendorp RG, Christensen K. (2012). Early-life environment influencing susceptibility to cytomegalovirus infection: evidence from the Leiden Longevity Study and the Longitudinal Study of Aging Danish Twins. Epidemiol Infect. 140(5):835-41.
  • Naumova E, Ivanova M, Pawelec G. (2011). Immunogenetics of ageing. Int J Immunogenet. 38: 373-81.
  • Naumova E, Ivanova M, Pawelec G, Constantinescu I, Bogunia-Kubik K, Lange A, Qguz F, Carin M, Franceschi C, Caruso C, Middleton D. (2011). 'Immunogenetics of Aging': report on the activities of the 15th International HLA and Immunogenetics Working Group and 15th International HLA and Immunogenetics Workshop. Tissue Antigens 77:187-192.
  • Pawelec G., Derhovanessian E. (2011). Role of CMV in immune senescence. Virus Res. 157(2):175-9.
  • Pawelec G, Akbar A, Beverley P, Caruso C, Derhovanessian E, Fülöp T, Griffiths P, Grubeck-Loebenstein B, Hamprecht K, Jahn G, Kern F, Koch SD, Larbi A, Maier AB, Macallan D, Moss P, Samson S, Strindhall J, Trannoy E, Wills M. (2010). Immunosenescence and Cytomegalovirus: where do we stand after a decade? Immun Ageing. 7:13.
  • Pawelec G. (2009). Accumulations of KIR+ T cells in the elderly. Blood 114:3360-1.
  • Pawelec G., Derhovanessian E., Larbi A., Strindhall J., Wikby A. (2009). Cytomegalovirus and human immunosenescence. Rev Med Virol. 19:47-56.
  • Simanek AM, Dowd JB, Pawelec G, Melzer D, Dutta A, Aiello A. (2011). Seropositivity to Cytomegalovirus, Inflammation, All-Cause and Cardiovascular Disease-Related Mortality in the United States. PLoS ONE 6(2):e16103.
  • Skopeliti M., Iconomidou VA., Derhovanessian E., Pawelec G., Voelter W., Kalbacher H., Hamodrakas SJ., Tsitsilonis OE. (2009). Prothymosin alpha immunoactive carboxyl-terminal peptide TKKQKTDEDD stimulates lymphocyte reactions, induces dendritic cell maturation and adopts a beta-sheet conformation in a sequence-specific manner. Mol Immunol. 46:784-92.
  • Stegmaier P., Voss N., Meier T., Kel A., Wingender E., Borlak, J. (2011). Advanced computational biology methods identify molecular switches for malignancy in an EGF mouse model of liver cancer. PLoS ONE 6(3):e17738.
  • Uddin M., Aiello AE., Wildman DE., Koenen KC., Pawelec G., de los Santos R., Goldmann E., Galea S. (2010). Epigenetic and immune function profiles associated with post-traumatic stress disorder. PNAS 107:9470-5.
  • Victora, G.D., Schwickert, T.A., Fooksman, D.R., Meyer-Hermann, M., Dustin, M.L., Nussenzweig, M.C. (2010). Germinal center selection mechanism revealed by multiphoton microscopy using a photoactivatable fluorescent reporter. Cell 143, 592-605.
  • Voges B., Vallbracht S., Zimmer G., Bossow S., Neubert WJ., Richter K., Hobeika E., Herrler G., Ehl S. (2007). Recombinant Sendai virus induces T cell immunity against respiratory syncytial virus that is protective in the absence of antibodies. Cell Immunol. 247(2):85-94.
  • Wiegand MA., Bossow S., Schlecht S., Neubert WJ. (2007). De novo synthesis of N and P proteins as a key step in Sendai virus gene expression. J Virol. 81(24):13835-44.
  • Zawacka-Pankau J., Grinkevich VV., Hunten S., Nikulenkov F., Gluch A., Li H., Enge M., Kel A., Selivanova G. (2011). Inhibition of glycolytic enzymes mediated by pharmacologically activated p53: targeting Warburg effect to fight cancer. J. Biol. Chem. 286(48):41600-15.
04.12.2016